Workshop on perinatal exposure to dioxin-like compounds. I. Summary.
نویسندگان
چکیده
An international workshop reviewed 20 ongoing or recently completed studies of the effects of perinatal exposures to dioxins, dibenzofurans, and PCBs on the reproductive, endocrine, neurodevelopmental, and immune systems. Many of the observed effects are consistent with these compounds acting as "environmental hormones" or endocrine disrupters. This report summarizes the conclusions and future directions described at the workshop.
منابع مشابه
Workshop on perinatal exposure to dioxin-like compounds. II. Reproductive effects.
This summary report focuses on current studies on reproductive effects reported at the workshop on Perinatal Exposure to Dioxin-like Compounds and supporting data noted in the discussion. Recent laboratory studies have suggested that altered development (e.g., low birth weight, spontaneous abortion, congenital malformation) and reproductive health (e.g., fertility, sex organ development, reprod...
متن کاملWorkshop on perinatal exposure to dioxin-like compounds. III. Endocrine effects.
Studies involving endocrine effects in humans and experimental animals resulting from the exposure to dioxin-like (non-ortho-substituted PCBs, PCDDs/PCDFs) and nondioxin-like (PCBs, OC pesticides) compounds (DLCs and NDLCs) were presented. A variety of reproductive and hormonal parameters, including androgen status, sexual differentiation, and thyroid functionality, were discussed. As in utero ...
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The immune system comprises a highly integrated network of multiple tissues and cell types with complicated interactions and effects. It is modulated by the endocrine and nervous systems and there is growing realization of its multifunctionality. The session focusing on immunologic effects of dioxin and related compounds following prenatal exposure involved a review of the immunotoxic effects t...
متن کاملWorkshop on perinatal exposure to dioxin-like compounds. IV. Neurobehavioral effects.
Nine participants outlined findings in the area of neurobehavioral effects of dioxin-like compounds and presented plans for new studies. Neurobehavioral effects are among the most sensitive and well studied toxicity end points for this class of compounds. A focus of the workshop was presentation of designs for major new studies in human populations outside the United States that are intended to...
متن کاملFindings on prenatal, lactational and later childhood exposure to dioxins and dioxin-like compounds: a review of the Amsterdam-Zaandam cohort 1987–2005
The Amsterdam-Zaandam cohort has been studied intermittently since 1987. The cohort was selected for optimal pregnancy and birth, in whom prenatal, lactational and more recently current dioxin exposures were measured. In the perinatal period and during the years thereafter, effects on various organ systems have been documented: thyroid, metabolism, immunity, haematology, motor development, brai...
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عنوان ژورنال:
- Environmental Health Perspectives
دوره 103 شماره
صفحات -
تاریخ انتشار 1995